Eosinophilic Esophagitis (EoE)

Lead drug candidate to treat Eosinophilic Esophagitis (EoE)

Eosinophilic Esophagitis (EoE) also known as “asthma of the esophagus” is a chronic immune-mediated disorder of the esophagus affecting both children and adults. EoE is a major cause of chronic esophagitis, second to gastro-esophageal reflux. Patients present with abdominal pain, vomiting, and dysphagia, difficulty swallowing and food impaction. It can be refractory to standard treatment with strict dietary food allergen avoidance, off-label use of swallowed topical steroids and proton pump inhibitors.

  • EoE is an orphan disease.
  • Overall prevalence is 57 per 100,000 United States children and adults up to age 64.
  • EoE profoundly impacts the quality of life in EoE patients.
  • This life-long disease of adults and children has a United States prevalence of approximately 181,000.
  • An economic burden of $1.4B in annual direct health care.
  • There are no FDA-approved EoE treatments.